Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P82insFs

c.244_245insAC

Surrounding Variants

9 papers

NM_000546.6

p.P82fs

c.244_245fs

12 papers

NM_000546.6

p.P82S

c.244C>T

11 papers

NM_000546.6

p.P82A

c.244C>G

1 paper

NM_000546.6

p.P82_A83ins16

c.244_248ins48

1 paper

NM_000546.6

p.T81_P82insFs

c.243_244insA

1 paper

NM_000546.6

p.P80_T81insFs

c.240_243dup4

9 papers

NM_000546.6

p.P82T

c.244C>A

1 paper

NM_000546.6

p.T81_P82Fs

c.242_244delinsTFs

2 papers

NM_000546.6

p.P80_T81delFs

c.240_243del4

1 paper

NM_000546.6

p.A78_T81del0

c.234_242del9

1 paper

NM_000546.6

p.A76_T81del6

c.226_242del18

4 papers

NM_000546.6

p.P75_T81delFs

c.225_243del19