Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T81T

c.243A>C

Surrounding Variants

6 papers

NM_000546.6

p.T81T

c.243A>G

9 papers

NM_000546.6

p.T81fs

c.241_242fs

4 papers

NM_000546.6

p.T81delFs

c.242delG

2 papers

NM_000546.6

p.P80_T81delFs

c.239_242del4

9 papers

NM_000546.6

p.P82fs

c.244_245fs

26 papers

NM_000546.6

p.T81I

c.242C>T

12 papers

NM_000546.6

p.P82S

c.244C>T

41 papers

NM_000546.6

p.T81R

c.242C>G

11 papers

NM_000546.6

p.P82A

c.244C>G

1 paper

NM_000546.6

p.P82insFs

c.244_245insAC

1 paper

NM_000546.6

p.P82_A83ins16

c.244_248ins48

6 papers

NM_000546.6

p.T81insFs

c.241_242insA