Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P80insFs

c.240dupT

Surrounding Variants

8 papers

NM_000546.6

p.T81S

c.241A>T

20 papers

NM_000546.6

p.T81A

c.241A>G

6 papers

NM_000546.6

p.T81P

c.241A>C

1 paper

NM_000546.6

p.P80_T81ins4

c.240_241ins12

2 papers

NM_000546.6

p.T81_P82ins6

c.241_245ins18

1 paper

NM_000546.6

p.P80_T81Fs

c.240_241delinsCFs

3 papers

NM_000546.6

p.P80delFs

c.240delA

1 paper

NM_000546.6

p.P80delins

c.240delinsT

2 papers

NM_000546.6

p.P80delFs

c.239_240delAG

1 paper

NM_000546.6

p.P80del1

c.238_239delAGG

1 paper

NM_000546.6

p.A79_P80del2

c.235_239del6

1 paper

NM_000546.6

p.P77_P80del4

c.229_239del12