Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

19 papers

NM_000546.6

p.P80S

c.238C>T

Surrounding Variants

10 papers

NM_000546.6

p.P80fs

c.238_239fs

50 papers

NM_000546.6

p.P80A

c.238C>G

NM_001126118.2

p.P41A

c.121C>G

6 papers

NM_000546.6

p.P80T

c.238C>A

2 papers

NM_000546.6

p.A79delFs

c.237delA

1 paper

NM_000546.6

p.A69_A79del11

c.205_236del33

2 papers

NM_000546.6

p.A79insFs

c.236dupC

1 paper

NM_000546.6

p.P77_A79insFs

c.229_235dup7

6 papers

NM_000546.6

p.A79fs

c.235_236fs

1 paper

NM_000546.6

p.A79A

c.237T>G

3 papers

NM_000546.6

p.A79A

c.237T>C

1 paper

NM_000546.6

p.A79A

c.237T>A

1 paper

NM_000546.6

p.A78_A79delFs

c.233_236del4