Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A79delFs

c.235delC

Surrounding Variants

15 papers

NM_000546.6

p.A79V

c.236C>T

13 papers

NM_000546.6

p.A79G

c.236C>G

1 paper

NM_000546.6

p.A79insFs

c.236_237insAC

9 papers

NM_000546.6

p.A79D

c.236C>A

1 paper

NM_000546.6

p.A79delins

c.235delinsG

1 paper

NM_000546.6

p.P67_A78del0

c.201_233del33

2 papers

NM_000546.6

p.A79insFs

c.236dupC

1 paper

NM_000546.6

p.P77_A79insFs

c.229_235dup7

6 papers

NM_000546.6

p.A79fs

c.235_236fs

1 paper

NM_000546.6

p.A79A

c.237T>G

3 papers

NM_000546.6

p.A79A

c.237T>C

1 paper

NM_000546.6

p.A79A

c.237T>A