Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P72_V73del1

c.216_218delACG

Surrounding Variants

2 papers

NM_000546.6

p.V73V

c.219G>T

1 paper

NM_000546.6

p.V73insFs

c.218_219insT

1 paper

NM_000546.6

p.V73insFs

c.218_219insTT

72 papers

NM_000546.6

p.V73fs

c.217_218fs

1 paper

NM_000546.6

p.V73V

c.219G>A

2 papers

NM_000546.6

p.V73delFs

c.218delA

1 paper

NM_000546.6

p.P71_V73del0

c.213_218del6

1 paper

NM_000546.6

p.V73insFs

c.217dupG

1 paper

NM_000546.6

p.V73insFs

c.217_218ins13

1 paper

NM_000546.6

p.P72_V73insFs

c.216_217dupCG

9 papers

NM_000546.6

p.V73G

c.218T>G

9 papers

NM_000546.6

p.V73A

c.218T>C