Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.V73G

c.218T>G

Surrounding Variants

1 paper

NM_000546.6

p.V73insFs

c.217dupG

1 paper

NM_000546.6

p.V73insFs

c.217_218ins13

1 paper

NM_000546.6

p.P72_V73insFs

c.216_217dupCG

9 papers

NM_000546.6

p.V73A

c.218T>C

8 papers

NM_000546.6

p.V73E

c.218T>A

1 paper

NM_000546.6

p.P72_V73Fs

c.215_218delinsGCGTCFs

1 paper

NM_000546.6

p.P72_V73Fs

c.215_218delinsGCFs

1 paper

NM_000546.6

p.P72_V73delins

c.215_218delinsGCTA

1 paper

NM_000546.6

p.P71_V73delFs

c.211_217del7

1 paper

NM_000546.6

p.P64_V73delFs

c.192_217del26

10 papers

NM_000546.6

p.V73L

c.217G>T

2 papers

NM_000546.6

p.V73V

c.219G>T