Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P72_V73Fs

c.215_217delinsGCFs

Surrounding Variants

10 papers

NM_000546.6

p.V73L

c.217G>T

48 papers

NM_000546.6

p.P72insFs

c.216dupC

1 paper

NM_000546.6

p.P72_V73insFs

c.216_217ins4

11 papers

NM_000546.6

p.V73L

c.217G>C

27 papers

NM_000546.6

p.V73M

c.217G>A

69 papers

NM_000546.6

p.V73fs

c.217_218fs

1 paper

NM_000546.6

p.P72_V73Fs

c.216_217delinsTFs

51 papers

NM_000546.6

p.P72delFs

c.216delG

7 papers

NM_000546.6

p.P71_P72delFs

c.213_214delGG

1 paper

NM_000546.6

p.P72_V73delins

c.215_217delinsGCA

2 papers

NM_000546.6

p.P72del1

c.214_215delGGG

1 paper

NM_000546.6

p.A69_P72delFs

c.206_215del10