Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.P72insFs

c.215_216insG

Surrounding Variants

18 papers

NM_000546.6

p.P72L

c.215C>T

1 paper

NM_000546.6

p.P72Fs

c.215delinsGTFs

854 papers

NM_000546.6

p.P72R

c.215C>G

NM_001126118.2

p.P33R

c.98C>G

1 paper

NM_000546.6

p.P72insFs

c.215_216ins7

1 paper

NM_000546.6

p.P72insFs

c.215_216ins7

23 papers

NM_000546.6

p.P72H

c.215C>A

NM_001126118.2

p.P33H

c.98C>A

1 paper

NM_000546.6

p.P72Fs

c.214_215delinsTFs

3 papers

NM_000546.6

p.P72Fs

c.214_215delinsGFs

2 papers

NM_000546.6

p.P72delins

c.214_215delinsTG

1 paper

NM_000546.6

p.P71_P72delins

c.213_215delinsCAA

1 paper

NM_000546.6

p.A70_P72delins

c.209_215delinsTCCCCCG

1 paper

NM_000546.6

p.P64_P71delFs

c.191_212del22