Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

51 papers

NM_000546.6

p.P72A

c.214C>G

Surrounding Variants

20 papers

NM_000546.6

p.P72S

c.214C>T

2 papers

NM_000546.6

p.P72insFs

c.214_215insG

1 paper

NM_000546.6

p.A69_P71insFs

c.206_212dup7

10 papers

NM_000546.6

p.P72T

c.214C>A

1 paper

NM_000546.6

p.P71_P72delins

c.213_214delinsTG

19 papers

NM_000546.6

p.P72fs

c.214_215fs

1 paper

NM_000546.6

p.A70_P71delFs

c.209_212del4

1 paper

NM_000546.6

p.E68_P71del4

c.202_212del12

18 papers

NM_000546.6

p.P72L

c.215C>T

1 paper

NM_000546.6

p.P71P

c.213C>T

1 paper

NM_000546.6

p.P72Fs

c.215delinsGTFs

854 papers

NM_000546.6

p.P72R

c.215C>G

NM_001126118.2

p.P33R

c.98C>G