Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.P71L

c.212C>T

NM_001126118.2

p.P32L

c.95C>T

Surrounding Variants

9 papers

NM_000546.6

p.P71R

c.212C>G

1 paper

NM_000546.6

p.P71insFs

c.212_213insG

1 paper

NM_000546.6

p.P71insFs

c.212_213ins7

6 papers

NM_000546.6

p.P71H

c.212C>A

1 paper

NM_000546.6

p.A70_P71delFs

c.210_211delGA

1 paper

NM_000546.6

p.A69_A70delFs

c.206_210del5

1 paper

NM_000546.6

p.R65_P71delFs

c.195_211del17

18 papers

NM_000546.6

p.P71S

c.211C>T

1 paper

NM_000546.6

p.P71P

c.213C>T

9 papers

NM_000546.6

p.P71A

c.211C>G

1 paper

NM_000546.6

p.P71P

c.213C>G

1 paper

NM_000546.6

p.P71_P72insFs

c.213_214insT