Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.A70V

c.209C>T

Surrounding Variants

9 papers

NM_000546.6

p.A70G

c.209C>G

1 paper

NM_000546.6

p.A70insFs

c.209_210insG

7 papers

NM_000546.6

p.A70D

c.209C>A

1 paper

NM_000546.6

p.A69_A70delFs

c.207_208delCA

5 papers

NM_000546.6

p.E68_A69del2

c.202_206del6

1 paper

NM_000546.6

p.A70_P71insFs

c.210_211insG

2 papers

NM_000546.6

p.A70insFs

c.209dupC

7 papers

NM_000546.6

p.A70fs

c.208_209fs

1 paper

NM_000546.6

p.A70A

c.210T>G

1 paper

NM_000546.6

p.A70A

c.210T>C

1 paper

NM_000546.6

p.A70A

c.210T>A

1 paper

NM_000546.6

p.A70delFs

c.209delG