Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.E68D

c.204G>C

Surrounding Variants

9 papers

NM_000546.6

p.E68D

c.204G>T

1 paper

NM_000546.6

p.E68_A69insFs

c.204_205ins7

1 paper

NM_000546.6

p.E68_A69insFs

c.204_205insAG

8 papers

NM_000546.6

p.E68fs

c.202_203fs

1 paper

NM_000546.6

p.E68insFs

c.203_204insA

4 papers

NM_000546.6

p.E68E

c.204G>A

1 paper

NM_000546.6

p.E68delFs

c.203delT

1 paper

NM_000546.6

p.D61_P67del7

c.181_200del21

9 papers

NM_000546.6

p.A69fs

c.205_206fs

7 papers

NM_000546.6

p.A69S

c.205G>T

1 paper

NM_000546.6

p.A69_A70insT

c.205_209ins3

12 papers

NM_000546.6

p.A69P

c.205G>C