Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

49 papers

NM_000546.6

p.E68*

c.202G>T

Surrounding Variants

1 paper

NM_000546.6

p.E68insFs

c.202_203insT

1 paper

NM_000546.6

p.P67insFs

c.201dupA

11 papers

NM_000546.6

p.E68Q

c.202G>C

16 papers

NM_000546.6

p.E68K

c.202G>A

4 papers

NM_000546.6

p.E68fs

c.202_203fs

1 paper

NM_000546.6

p.P67delFs

c.200_201delTG

1 paper

NM_000546.6

p.P64_P67del4

c.190_200del12

1 paper

NM_000546.6

p.D61_P67delFs

c.183_201del19

7 papers

NM_000546.6

p.E68V

c.203A>T

1 paper

NM_000546.6

p.P67P

c.201A>T

10 papers

NM_000546.6

p.E68G

c.203A>G

5 papers

NM_000546.6

p.P67P

c.201A>G