Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.R65_M66insFs

c.195_196insA

Surrounding Variants

5 papers

NM_000546.6

p.M66R

c.197T>G

10 papers

NM_000546.6

p.M66T

c.197T>C

6 papers

NM_000546.6

p.M66K

c.197T>A

3 papers

NM_000546.6

p.M66delFs

c.196delT

1 paper

NM_000546.6

p.R65del1

c.193_194delTCT

1 paper

NM_000546.6

p.G59_M66delFs

c.175_196del22

7 papers

NM_000546.6

p.M66I

c.198G>T

1 paper

NM_000546.6

p.M66Fs

c.198delinsCTTFs

2 papers

NM_000546.6

p.M66insFs

c.197dupT

2 papers

NM_000546.6

p.R65_M66insFs

c.193_197dup5

1 paper

NM_000546.6

p.M66_P67insFs

c.198_199insC

9 papers

NM_000546.6

p.M66fs

c.196_197fs