Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R65delFs

c.194_195delTC

Surrounding Variants

3 papers

NM_000546.6

p.M66fs

c.196_197fs

6 papers

NM_000546.6

p.M66L

c.196A>T

10 papers

NM_000546.6

p.M66V

c.196A>G

6 papers

NM_000546.6

p.M66L

c.196A>C

1 paper

NM_000546.6

p.M66insFs

c.196_197ins8

1 paper

NM_000546.6

p.M66_P67ins4

c.196_200ins12

1 paper

NM_000546.6

p.G59_R65del7

c.175_194del21

1 paper

NM_000546.6

p.P58_R65delFs

c.173_195del23

1 paper

NM_000546.6

p.T55_R65delFs

c.164_195del32

4 papers

NM_000546.6

p.R65_M66insFs

c.195_196insA

5 papers

NM_000546.6

p.M66R

c.197T>G

10 papers

NM_000546.6

p.M66T

c.197T>C