Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P64_R65del1

c.192_194delCTG

Surrounding Variants

5 papers

NM_000546.6

p.R65S

c.195A>T

2 papers

NM_000546.6

p.R65R

c.195A>G

6 papers

NM_000546.6

p.R65S

c.195A>C

3 papers

NM_000546.6

p.R65_M66insFs

c.195_196insT

17 papers

NM_000546.6

p.R65fs

c.193_194fs

1 paper

NM_000546.6

p.R65_M66insFs

c.195_196ins4

8 papers

NM_000546.6

p.R65I

c.194G>T

1 paper

NM_000546.6

p.R65insFs

c.193_194insA

12 papers

NM_000546.6

p.R65T

c.194G>C

14 papers

NM_000546.6

p.R65K

c.194G>A

3 papers

NM_000546.6

p.M66fs

c.196_197fs

2 papers

NM_000546.6

p.R65delFs

c.193delT