Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R65R

c.193A>C

Surrounding Variants

44 papers

NM_000546.6

p.R65*

c.193A>T

11 papers

NM_000546.6

p.R65G

c.193A>G

3 papers

NM_000546.6

p.P64insFs

c.192dupC

1 paper

NM_000546.6

p.R65_M66ins4

c.193_197ins12

11 papers

NM_000546.6

p.R65fs

c.193_194fs

8 papers

NM_000546.6

p.P64delFs

c.192delG

1 paper

NM_000546.6

p.P64delFs

c.191_192delGG

1 paper

NM_000546.6

p.A63_P64delFs

c.188_192del5

1 paper

NM_000546.6

p.T55_P64delFs

c.164_192del29

8 papers

NM_000546.6

p.R65I

c.194G>T

1 paper

NM_000546.6

p.R65insFs

c.193_194insA

12 papers

NM_000546.6

p.R65T

c.194G>C