Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.A63A

c.189T>C

Surrounding Variants

1 paper

NM_000546.6

p.A63_P64insFs

c.189_190insG

1 paper

NM_000546.6

p.A63fs

c.187_188fs

1 paper

NM_000546.6

p.A63_P64insFs

c.189_190insA

4 papers

NM_000546.6

p.A63Fs

c.189delinsAGAFs

1 paper

NM_000546.6

p.E62_A63delFs

c.184_188del5

47 papers

NM_000546.6

p.P64S

c.190C>T

30 papers

NM_000546.6

p.A63V

c.188C>T

16 papers

NM_000546.6

p.A63G

c.188C>G

9 papers

NM_000546.6

p.P64A

c.190C>G

1 paper

NM_000546.6

p.A63insFs

c.188_189insGT

1 paper

NM_000546.6

p.E56_E62ins2

c.168_185dup18

8 papers

NM_000546.6

p.P64T

c.190C>A