Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.E62fs

c.184_185fs

Surrounding Variants

38 papers

NM_000546.6

p.E62*

c.184G>T

NM_001126118.2

p.E23*

c.67G>T

1 paper

NM_000546.6

p.E62insFs

c.184_185insA

11 papers

NM_000546.6

p.E62Q

c.184G>C

17 papers

NM_000546.6

p.E62K

c.184G>A

1 paper

NM_000546.6

p.D61_E62delins

c.183_184delinsCT

1 paper

NM_000546.6

p.P60_D61delFs

c.180_183del4

7 papers

NM_000546.6

p.G59_D61del0

c.177_182del6

3 papers

NM_000546.6

p.D61fs

c.181_182fs

11 papers

NM_000546.6

p.D61E

c.183T>G

3 papers

NM_000546.6

p.D61D

c.183T>C

10 papers

NM_000546.6

p.D61E

c.183T>A

5 papers

NM_000546.6

p.D61delFs

c.182delT