Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P58_G59del2

c.172_176del6

Surrounding Variants

39 papers

NM_000546.6

p.D61V

c.182A>T

58 papers

NM_000546.6

p.D61G

c.182A>G

17 papers

NM_000546.6

p.D61A

c.182A>C

1 paper

NM_000546.6

p.D61insFs

c.182_183insT

3 papers

NM_000546.6

p.D61fs

c.181_182fs

11 papers

NM_000546.6

p.D61E

c.183T>G

3 papers

NM_000546.6

p.D61D

c.183T>C

10 papers

NM_000546.6

p.D61E

c.183T>A

5 papers

NM_000546.6

p.D61delFs

c.182delT

3 papers

NM_000546.6

p.D61delFs

c.181_182delTC

3 papers

NM_000546.6

p.D61fs

c.181_182fs

1 paper

NM_000546.6

p.D57_P60del4

c.169_179del12