Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.P60fs

c.178_179fs

Surrounding Variants

2 papers

NM_000546.6

p.P60P

c.180A>C

1 paper

NM_000546.6

p.P60insFs

c.179dupC

4 papers

NM_000546.6

p.P60delFs

c.178delG

1 paper

NM_000546.6

p.P60delFs

c.178_179delGG

1 paper

NM_000546.6

p.F54_P60del0

c.162_179del18

1 paper

NM_000546.6

p.Q52_P60delFs

c.154_179del26

3 papers

NM_000546.6

p.D61fs

c.181_182fs

13 papers

NM_000546.6

p.D61Y

c.181G>T

1 paper

NM_000546.6

p.D61insFs

c.181_182ins5

8 papers

NM_000546.6

p.D61H

c.181G>C

16 papers

NM_000546.6

p.D61N

c.181G>A

1 paper

NM_000546.6

p.P60delFs

c.179_180delTG