Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T55insFs

c.164dupC

Surrounding Variants

2 papers

NM_000546.6

p.T55fs

c.163_164fs

1 paper

NM_000546.6

p.T55T

c.165T>G

2 papers

NM_000546.6

p.T55T

c.165T>C

1 paper

NM_000546.6

p.Q52_T55delFs

c.155_164del10

56 papers

NM_000546.6

p.E56*

c.166G>T

1 paper

NM_000546.6

p.T55insFs

c.165dupT

1 paper

NM_000546.6

p.E56_D57insGCC

c.166_170ins9

8 papers

NM_000546.6

p.E56Q

c.166G>C

17 papers

NM_000546.6

p.E56K

c.166G>A

5 papers

NM_000546.6

p.T55delFs

c.165delA

1 paper

NM_000546.6

p.F54_T55del2

c.160_164del6

1 paper

NM_000546.6

p.W53_T55del3

c.157_164del9