Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.F54fs

c.160_161fs

Surrounding Variants

1 paper

NM_000546.6

p.W53_F54insFs

c.159_160insG

1 paper

NM_000546.6

p.F54_T55insA

c.160_164ins3

1 paper

NM_000546.6

p.F54_T55insAT

c.160_164ins6

9 papers

NM_000546.6

p.F54V

c.160T>G

16 papers

NM_000546.6

p.F54L

c.160T>C

10 papers

NM_000546.6

p.F54I

c.160T>A

3 papers

NM_000546.6

p.W53delFs

c.159delC

1 paper

NM_000546.6

p.E51_W53delFs

c.153_159del7

7 papers

NM_000546.6

p.F54C

c.161T>G

48 papers

NM_000546.6

p.F54S

c.161T>C

14 papers

NM_000546.6

p.F54Y

c.161T>A

3 papers

NM_000546.6

p.W53del1

c.157_158delCCA