Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q52_W53del1

c.156_158delCAT

Surrounding Variants

12 papers

NM_000546.6

p.W53C

c.159G>T

4 papers

NM_000546.6

p.Q52_W53insFs

c.155_158dup4

7 papers

NM_000546.6

p.W53fs

c.157_158fs

15 papers

NM_000546.6

p.W53C

c.159G>C

150 papers

NM_000546.6

p.W53*

c.159G>A

1 paper

NM_000546.6

p.W53delins

c.158_159delinsAA

1 paper

NM_000546.6

p.E51_W53delFs

c.152_158del7

1 paper

NM_000546.6

p.W53_F54insFs

c.159_160insG

1 paper

NM_000546.6

p.F54_T55insA

c.160_164ins3

1 paper

NM_000546.6

p.F54_T55insAT

c.160_164ins6

9 papers

NM_000546.6

p.F54V

c.160T>G

16 papers

NM_000546.6

p.F54L

c.160T>C