Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.Q52delFs

c.156delT

Surrounding Variants

7 papers

NM_000546.6

p.Q52insFs

c.156dupA

10 papers

NM_000546.6

p.W53G

c.157T>G

11 papers

NM_000546.6

p.W53R

c.157T>C

10 papers

NM_000546.6

p.W53R

c.157T>A

1 paper

NM_000546.6

p.Q52delFs

c.155_156delTT

2 papers

NM_000546.6

p.E51_Q52delFs

c.152_156del5

11 papers

NM_000546.6

p.W53fs

c.157_158fs

14 papers

NM_000546.6

p.W53L

c.158G>T

2 papers

NM_000546.6

p.W53insFs

c.157dupT

2 papers

NM_000546.6

p.Q52_W53ins0

c.155_157dupAAT

1 paper

NM_000546.6

p.W53insFs

c.158_159ins4

10 papers

NM_000546.6

p.W53S

c.158G>C