Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

53 papers

NM_000546.6

p.Q52*

c.154C>T

NM_001276696.3

p.Q13*

c.37C>T

Surrounding Variants

8 papers

NM_000546.6

p.Q52E

c.154C>G

1 paper

NM_000546.6

p.E51_Q52insFs

c.153_154insA

8 papers

NM_000546.6

p.Q52K

c.154C>A

1 paper

NM_000546.6

p.E51delFs

c.153delT

1 paper

NM_000546.6

p.E51delFs

c.152_153delTT

1 paper

NM_000546.6

p.I50_E51delFs

c.149_153del5

2 papers

NM_000546.6

p.D49_E51delFs

c.147_153del7

1 paper

NM_000546.6

p.M44_E51del8

c.130_152del24

17 papers

NM_000546.6

p.Q52fs

c.154_155fs

8 papers

NM_000546.6

p.Q52L

c.155A>T

8 papers

NM_000546.6

p.E51D

c.153A>T

12 papers

NM_000546.6

p.Q52R

c.155A>G