Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.E51D

c.153A>T

Surrounding Variants

4 papers

NM_000546.6

p.E51E

c.153A>G

8 papers

NM_000546.6

p.E51D

c.153A>C

10 papers

NM_000546.6

p.E51fs

c.151_152fs

1 paper

NM_000546.6

p.I50_E51delFs

c.149_152del4

1 paper

NM_000546.6

p.D49_I50del2

c.145_149del6

1 paper

NM_000546.6

p.D48_I50del3

c.142_149del9

1 paper

NM_000546.6

p.S46_E51del0

c.138_152del15

1 paper

NM_000546.6

p.S46_E51delFs

c.136_152del17

1 paper

NM_000546.6

p.M44_E51del0

c.132_152del21

53 papers

NM_000546.6

p.Q52*

c.154C>T

NM_001276696.3

p.Q13*

c.37C>T

8 papers

NM_000546.6

p.Q52E

c.154C>G

1 paper

NM_000546.6

p.E51_Q52insFs

c.153_154insA