Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.E51Q

c.151G>C

Surrounding Variants

53 papers

NM_000546.6

p.E51*

c.151G>T

2 papers

NM_000546.6

p.I50_E51insFs

c.150_151insT

16 papers

NM_000546.6

p.E51K

c.151G>A

NM_001126118.2

p.E12K

c.34G>A

5 papers

NM_000546.6

p.I50delFs

c.150delA

2 papers

NM_000546.6

p.I50delFs

c.149_150delAA

1 paper

NM_000546.6

p.I50del1

c.148_149delAAT

1 paper

NM_000546.6

p.D49_I50delFs

c.147_150del4

3 papers

NM_000546.6

p.P47_I50del4

c.139_149del12

1 paper

NM_000546.6

p.S46_I50delFs

c.137_150del14

2 papers

NM_000546.6

p.L45_I50del6

c.133_149del18

12 papers

NM_000546.6

p.E51fs

c.151_152fs

12 papers

NM_000546.6

p.I50fs

c.148_149fs