Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.I50S

c.149T>G

Surrounding Variants

5 papers

NM_000546.6

p.I50insFs

c.148dupA

1 paper

NM_000546.6

p.I50insFs

c.149_150ins13

29 papers

NM_000546.6

p.I50T

c.149T>C

12 papers

NM_000546.6

p.I50N

c.149T>A

2 papers

NM_000546.6

p.I50delFs

c.148delT

1 paper

NM_000546.6

p.L45_I50delFs

c.133_148del16

1 paper

NM_000546.6

p.D41_I50del0

c.122_148del27

12 papers

NM_000546.6

p.I50fs

c.148_149fs

10 papers

NM_000546.6

p.I50M

c.150T>G

2 papers

NM_000546.6

p.I50I

c.150T>C

13 papers

NM_000546.6

p.I50I

c.150T>A

1 paper

NM_000546.6

p.D49_I50delFs

c.147_148delTA