Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.I50L

c.148A>C

Surrounding Variants

8 papers

NM_000546.6

p.I50fs

c.148_149fs

28 papers

NM_000546.6

p.I50F

c.148A>T

10 papers

NM_000546.6

p.I50V

c.148A>G

1 paper

NM_000546.6

p.D49del1

c.145_147delATC

1 paper

NM_000546.6

p.M44_D49delFs

c.132_147del16

1 paper

NM_000546.6

p.D42_D49del0

c.126_146del21

2 papers

NM_000546.6

p.D49_I50insFs

c.147_148insC

11 papers

NM_000546.6

p.D49fs

c.145_146fs

5 papers

NM_000546.6

p.I50insFs

c.148dupA

1 paper

NM_000546.6

p.I50insFs

c.149_150ins13

11 papers

NM_000546.6

p.D49E

c.147T>G

9 papers

NM_000546.6

p.I50S

c.149T>G