Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.D49E

c.147T>A

Surrounding Variants

2 papers

NM_000546.6

p.D49_I50insFs

c.147_148insC

11 papers

NM_000546.6

p.D49fs

c.145_146fs

11 papers

NM_000546.6

p.D49E

c.147T>G

3 papers

NM_000546.6

p.D49D

c.147T>C

3 papers

NM_000546.6

p.D49delFs

c.146delT

2 papers

NM_000546.6

p.D49delFs

c.145_146delTC

1 paper

NM_000546.6

p.D48_D49delFs

c.142_146del5

8 papers

NM_000546.6

p.I50fs

c.148_149fs

57 papers

NM_000546.6

p.D49V

c.146A>T

28 papers

NM_000546.6

p.I50F

c.148A>T

15 papers

NM_000546.6

p.D49G

c.146A>G

10 papers

NM_000546.6

p.I50V

c.148A>G