Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D48delFs

c.144delG

Surrounding Variants

8 papers

NM_000546.6

p.D49fs

c.145_146fs

13 papers

NM_000546.6

p.D49Y

c.145G>T

62 papers

NM_000546.6

p.D49H

c.145G>C

32 papers

NM_000546.6

p.D49N

c.145G>A

1 paper

NM_000546.6

p.S46_D48del0

c.138_143del6

1 paper

NM_000546.6

p.L45_D48del4

c.133_143del12

5 papers

NM_000546.6

p.D48D

c.144C>T

15 papers

NM_000546.6

p.D48E

c.144C>G

1 paper

NM_000546.6

p.D48_D49insFs

c.144_145ins5

20 papers

NM_000546.6

p.D48fs

c.142_143fs

14 papers

NM_000546.6

p.D48E

c.144C>A

1 paper

NM_000546.6

p.D48delins

c.143_144delinsCT