Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

21 papers

NM_001126118.2

p.P8delFs

c.23delG

NM_000546.6

p.P47delFs

c.140delG

Surrounding Variants

1 paper

NM_000546.6

p.P47P

c.141G>T

2 papers

NM_000546.6

p.S46insFs

c.137_138insC

1 paper

NM_000546.6

p.P47insFs

c.139_140dupCC

15 papers

NM_001126118.2

p.P8fs

c.22_23fs

NM_000546.6

p.P47fs

c.139_140fs

10 papers

NM_001126118.2

p.P8P

c.24G>A

NM_000546.6

p.P47P

c.141G>A

13 papers

NM_000546.6

p.D48Y

c.142G>T

13 papers

NM_000546.6

p.D48H

c.142G>C

19 papers

NM_000546.6

p.D48N

c.142G>A

1 paper

NM_000546.6

p.P47del1

c.139_140delCGG

1 paper

NM_000546.6

p.S46_P47delFs

c.137_141del5

1 paper

NM_000546.6

p.S46_P47del2

c.136_140del6

1 paper

NM_000546.6

p.L43_P47delFs

c.128_141del14