Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P47delins

c.139_140delinsTT

Surrounding Variants

18 papers

NM_000546.6

p.P47L

c.140C>T

13 papers

NM_000546.6

p.P47R

c.140C>G

1 paper

NM_000546.6

p.P47insFs

c.140_141ins4

1 paper

NM_000546.6

p.M40_P47ins2

c.119_139dup21

7 papers

NM_000546.6

p.P47Q

c.140C>A

1 paper

NM_000546.6

p.P47P

c.141G>T

2 papers

NM_000546.6

p.S46insFs

c.137_138insC

1 paper

NM_000546.6

p.P47insFs

c.139_140dupCC

15 papers

NM_001126118.2

p.P8fs

c.22_23fs

NM_000546.6

p.P47fs

c.139_140fs

10 papers

NM_001126118.2

p.P8P

c.24G>A

NM_000546.6

p.P47P

c.141G>A

21 papers

NM_001126118.2

p.P8delFs

c.23delG

NM_000546.6

p.P47delFs

c.140delG

17 papers

NM_000546.6

p.P47fs

c.139_140fs