Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S46_P47delins

c.138_139delinsGT

Surrounding Variants

17 papers

NM_000546.6

p.P47fs

c.139_140fs

185 papers

NM_000546.6

p.P47S

c.139C>T

NM_001126118.2

p.P8S

c.22C>T

1 paper

NM_000546.6

p.P47Fs

c.139delinsTTFs

12 papers

NM_000546.6

p.P47A

c.139C>G

15 papers

NM_000546.6

p.P47T

c.139C>A

1 paper

NM_000546.6

p.S46_P47delins

c.138_139delinsTT

1 paper

NM_000546.6

p.S46del1

c.136_137delGGA

1 paper

NM_000546.6

p.M44_S46del0

c.130_138del9

1 paper

NM_000546.6

p.L43_S46delFs

c.128_138del11

18 papers

NM_000546.6

p.P47L

c.140C>T

1 paper

NM_000546.6

p.S46S

c.138C>T

13 papers

NM_000546.6

p.P47R

c.140C>G