Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S46S

c.138C>G

Surrounding Variants

1 paper

NM_000546.6

p.S46S

c.138C>T

6 papers

NM_000546.6

p.S46fs

c.136_137fs

2 papers

NM_000546.6

p.S46S

c.138C>A

2 papers

NM_000546.6

p.S46delFs

c.136_137delGA

17 papers

NM_000546.6

p.P47fs

c.139_140fs

185 papers

NM_000546.6

p.P47S

c.139C>T

NM_001126118.2

p.P8S

c.22C>T

36 papers

NM_000546.6

p.S46F

c.137C>T

NM_001126118.2

p.S7F

c.20C>T

1 paper

NM_000546.6

p.P47Fs

c.139delinsTTFs

1 paper

NM_000546.6

p.S46Fs

c.137delinsGTFs

12 papers

NM_000546.6

p.P47A

c.139C>G

8 papers

NM_000546.6

p.S46C

c.137C>G

15 papers

NM_000546.6

p.P47T

c.139C>A