Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.D42H

c.124G>C

Surrounding Variants

6 papers

NM_000546.6

p.D42fs

c.124_125fs

14 papers

NM_000546.6

p.D42Y

c.124G>T

1 paper

NM_000546.6

p.D41insFs

c.123dupT

1 paper

NM_000546.6

p.A39_D41insFs

c.116_123dup8

1 paper

NM_000546.6

p.D42_L43ins13

c.124_128ins39

21 papers

NM_000546.6

p.D42N

c.124G>A

1 paper

NM_000546.6

p.D41delFs

c.123delA

1 paper

NM_000546.6

p.P36_D41del6

c.106_122del18

6 papers

NM_000546.6

p.D41fs

c.121_122fs

1 paper

NM_000546.6

p.D41insFs

c.122dupA

10 papers

NM_000546.6

p.D41E

c.123T>G

2 papers

NM_000546.6

p.D41D

c.123T>C