Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.Q38K

c.112C>A

Surrounding Variants

55 papers

NM_000546.6

p.Q38*

c.112C>T

8 papers

NM_000546.6

p.Q38E

c.112C>G

2 papers

NM_000546.6

p.Q38_A39insG

c.112_116ins3

1 paper

NM_000546.6

p.Q38_A39insCT

c.112_116ins6

1 paper

NM_000546.6

p.S37_Q38delins

c.111_112delinsTT

2 papers

NM_000546.6

p.L35_S37delFs

c.105_111del7

1 paper

NM_000546.6

p.L35_S37del3

c.103_110del9

9 papers

NM_000546.6

p.Q38fs

c.112_113fs

4 papers

NM_000546.6

p.S37S

c.111C>T

1 paper

NM_000546.6

p.S37S

c.111C>G

1 paper

NM_000546.6

p.S37insFs

c.109_110ins5

5 papers

NM_000546.6

p.S37fs

c.109_110fs