Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S37S

c.111C>T

Surrounding Variants

1 paper

NM_000546.6

p.S37S

c.111C>G

1 paper

NM_000546.6

p.S37insFs

c.109_110ins5

5 papers

NM_000546.6

p.S37fs

c.109_110fs

2 papers

NM_000546.6

p.S37S

c.111C>A

1 paper

NM_000546.6

p.P36_S37del1

c.108_110delGAC

55 papers

NM_000546.6

p.Q38*

c.112C>T

35 papers

NM_000546.6

p.S37F

c.110C>T

26 papers

NM_000546.6

p.S37C

c.110C>G

8 papers

NM_000546.6

p.Q38E

c.112C>G

2 papers

NM_000546.6

p.Q38_A39insG

c.112_116ins3

1 paper

NM_000546.6

p.Q38_A39insCT

c.112_116ins6

11 papers

NM_000546.6

p.S37Y

c.110C>A