Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

16 papers

NM_000546.6

p.S37P

c.109T>C

Surrounding Variants

42 papers

NM_000546.6

p.S37A

c.109T>G

9 papers

NM_000546.6

p.S37T

c.109T>A

5 papers

NM_000546.6

p.P36delFs

c.108delC

2 papers

NM_000546.6

p.P36del1

c.106_108delCGG

2 papers

NM_000546.6

p.L35_P36delFs

c.105_108del4

1 paper

NM_000546.6

p.S33_S37Fs

c.98_109delinsGFs

5 papers

NM_000546.6

p.S37fs

c.109_110fs

3 papers

NM_000546.6

p.P36P

c.108G>T

1 paper

NM_000546.6

p.P36_S37insFs

c.108_109insTG

1 paper

NM_000546.6

p.P36insFs

c.107dupC

15 papers

NM_000546.6

p.P36fs

c.106_107fs

1 paper

NM_000546.6

p.P36_S37insFs

c.108_109ins5