Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L35*

c.104T>A

Surrounding Variants

1 paper

NM_000546.6

p.L35insFs

c.104_105insA

12 papers

NM_000546.6

p.L35W

c.104T>G

9 papers

NM_000546.6

p.L35S

c.104T>C

1 paper

NM_000546.6

p.P34_L35del1

c.101_103delAGG

1 paper

NM_000546.6

p.P34_L35delFs

c.100_103del4

20 papers

NM_000546.6

p.P34insFs

c.102dupC

1 paper

NM_000546.6

p.S33_P34insFs

c.99_100ins4

8 papers

NM_000546.6

p.L35V

c.103T>G

1 paper

NM_000546.6

p.L35L

c.103T>C

9 papers

NM_000546.6

p.L35M

c.103T>A

20 papers

NM_000546.6

p.P34delFs

c.101delG

1 paper

NM_000546.6

p.P34delFs

c.101_102delGG