Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

24 papers

NM_000546.6

p.P34L

c.101C>T

Surrounding Variants

17 papers

NM_000546.6

p.P34R

c.101C>G

1 paper

NM_000546.6

p.P34Fs

c.100delinsCGFs

1 paper

NM_000546.6

p.S33_P34insFs

c.97_100dup4

4 papers

NM_000546.6

p.P34H

c.101C>A

1 paper

NM_000546.6

p.P34delins

c.100_101delinsTT

1 paper

NM_000546.6

p.S33_P34delFs

c.97_100del4

17 papers

NM_000546.6

p.P34S

c.100C>T

2 papers

NM_000546.6

p.P34P

c.102C>T

14 papers

NM_000546.6

p.P34A

c.100C>G

5 papers

NM_000546.6

p.P34P

c.102C>G

1 paper

NM_000546.6

p.P34insFs

c.101_102insCG

12 papers

NM_000546.6

p.P34fs

c.100_101fs