Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S33S

c.99C>A

Surrounding Variants

2 papers

NM_000546.6

p.S33S

c.99C>T

15 papers

NM_000546.6

p.S33fs

c.97_98fs

21 papers

NM_000546.6

p.S33F

c.98C>T

17 papers

NM_000546.6

p.P34S

c.100C>T

63 papers

NM_000546.6

p.S33C

c.98C>G

14 papers

NM_000546.6

p.P34A

c.100C>G

4 papers

NM_000546.6

p.S33insFs

c.97dupT

1 paper

NM_000546.6

p.S33insFs

c.98_99insG

1 paper

NM_000546.6

p.S33insFs

c.98_99ins4

1 paper

NM_000546.6

p.P34_L35insCT

c.100_104ins6

22 papers

NM_000546.6

p.S33Y

c.98C>A

12 papers

NM_000546.6

p.P34T

c.100C>A