Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.L32fs

c.94_95fs

Surrounding Variants

1 paper

NM_000546.6

p.L32L

c.96G>T

1 paper

NM_000546.6

p.L32insFs

c.95dupT

1 paper

NM_000546.6

p.L32insFs

c.94_95dupCT

1 paper

NM_000546.6

p.L32_S33insFs

c.96_97insAG

1 paper

NM_000546.6

p.L32_S33insFs

c.96_97insA

1 paper

NM_000546.6

p.L32L

c.96G>C

3 papers

NM_000546.6

p.L32L

c.96G>A

2 papers

NM_000546.6

p.L32delFs

c.95delA

1 paper

NM_000546.6

p.L32delFs

c.94_95delAG

1 paper

NM_000546.6

p.V31_L32del1

c.93_95delAGA

1 paper

NM_000546.6

p.L32insFs

c.94dupC

9 papers

NM_000546.6

p.L32R

c.95T>G