Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.L32fs

c.94_95fs

Surrounding Variants

3 papers

NM_000546.6

p.L32L

c.94C>T

11 papers

NM_000546.6

p.L32V

c.94C>G

1 paper

NM_000546.6

p.V31insFs

c.92_93insT

1 paper

NM_000546.6

p.L32insFs

c.94_95insTA

10 papers

NM_000546.6

p.L32M

c.94C>A

4 papers

NM_000546.6

p.V31delFs

c.93delA

1 paper

NM_000546.6

p.V31delFs

c.92_93delAA

1 paper

NM_000546.6

p.L32insFs

c.94dupC

2 papers

NM_000546.6

p.V31fs

c.91_92fs

9 papers

NM_000546.6

p.L32R

c.95T>G

3 papers

NM_000546.6

p.V31V

c.93T>G

8 papers

NM_000546.6

p.L32P

c.95T>C