Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.V31L

c.91G>C

Surrounding Variants

10 papers

NM_000546.6

p.V31F

c.91G>T

1 paper

NM_000546.6

p.V31insFs

c.91_92insT

1 paper

NM_000546.6

p.V31insFs

c.91_92ins10

1 paper

NM_000546.6

p.N30insFs

c.90dupC

128 papers

NM_000546.6

p.V31I

c.91G>A

3 papers

NM_000546.6

p.N30delFs

c.90delG

5 papers

NM_000546.6

p.N30del1

c.88_90delGTT

1 paper

NM_000546.6

p.P27_N30del0

c.79_90del12

1 paper

NM_000546.6

p.V31insFs

c.92_93insAA

12 papers

NM_000546.6

p.V31G

c.92T>G

8 papers

NM_000546.6

p.V31A

c.92T>C

8 papers

NM_000546.6

p.V31D

c.92T>A