Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P27P

c.81T>G

Surrounding Variants

1 paper

NM_000546.6

p.P27insFs

c.79_80dupCC

2 papers

NM_000546.6

p.P27_E28ins2

c.81_82ins6

18 papers

NM_000546.6

p.P27fs

c.79_80fs

9 papers

NM_000546.6

p.P27P

c.81T>C

17 papers

NM_000546.6

p.P27P

c.81T>A

25 papers

NM_000546.6

p.P27delFs

c.80delG

1 paper

NM_000546.6

p.P27delFs

c.79_80delGG

3 papers

NM_000546.6

p.E28*

c.82G>T

1 paper

NM_000546.6

p.E28insFs

c.82_83ins16

1 paper

NM_000546.6

p.L26_P27ins0

c.78_80dupTCC

1 paper

NM_000546.6

p.L26_P27insFs

c.77_80dup4

11 papers

NM_000546.6

p.E28Q

c.82G>C