Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.W23_K24ins1

c.69_70insATT

Surrounding Variants

12 papers

NM_000546.6

p.W23C

c.69G>T

1 paper

NM_000546.6

p.W23_K24insFs

c.69_70insT

1 paper

NM_000546.6

p.W23_K24insFs

c.69_70insC

12 papers

NM_000546.6

p.W23C

c.69G>C

9 papers

NM_000546.6

p.W23*

c.69G>A

1 paper

NM_000546.6

p.L22_W23del1

c.66_68delCAT

1 paper

NM_000546.6

p.D21_W23delFs

c.61_67del7

10 papers

NM_000546.6

p.W23L

c.68G>T

106 papers

NM_000546.6

p.W23S

c.68G>C

11 papers

NM_000546.6

p.W23*

c.68G>A

1 paper

NM_000546.6

p.W23delFs

c.67delA

12 papers

NM_000546.6

p.K24*

c.70A>T