Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.W23fs

c.67_68fs

Surrounding Variants

5 papers

NM_000546.6

p.L22insFs

c.66dupA

11 papers

NM_000546.6

p.W23G

c.67T>G

9 papers

NM_000546.6

p.W23R

c.67T>C

8 papers

NM_000546.6

p.W23delins

c.67_68delinsAG

1 paper

NM_000546.6

p.S20_L22delFs

c.59_66del8

1 paper

NM_000546.6

p.T18_L22delFs

c.53_66del14

10 papers

NM_000546.6

p.W23L

c.68G>T

106 papers

NM_000546.6

p.W23S

c.68G>C

11 papers

NM_000546.6

p.W23*

c.68G>A

1 paper

NM_000546.6

p.W23delFs

c.67delA

6 papers

NM_000546.6

p.L22L

c.66A>T

3 papers

NM_000546.6

p.L22L

c.66A>G